Samuel de Champlain left the port of Honfleur in 1604 and founded Acadia. Four years later, he founded Quebec City. From then onwards, Normans engaged in a policy of expansion in North America. They continued the exploration of the New World: René Robert Cavelier de La Salle traveled in the area of the Great Lakes, then on the Mississippi River. Pierre Le Moyne d’Iberville and his brother Lemoyne de Bienville founded Louisiana, Biloxi, Mobile and New Orleans. Territories located between Quebec and the Mississippi Delta were opened up to establish Canada and Louisiana. Colonists from Normandy were among the most active in New France, comprising Acadia, Canada, and Louisiana.